Genetics and reproductive biotechnologies

Head of the research group: Mgr. Miluše Vozdová, Ph.D.
Phone: +420 721 441 422
E-mail: miluse.vozdova@vri.cz

The group focuses on cytogenetics, genetics, and genomics of farm animals, pets, exotic animals, and humans. Using laser microdissection, we prepare specific “custom” DNA probes for chromosomes of various species and use them to study evolutionary karyotype rearrangements and for phylogenetic analysis with implications for taxonomy and systematics. The group also focuses on the detection of congenital and acquired chromosomal aberrations in animals and humans, searches for genetic markers associated with oncological diseases, and studies the impact of genotoxic agents on DNA methylation, mitochondrial DNA, and chromosomes. In the field of reproduction, the group focuses on the analysis of ejaculate and insemination dose quality and on the molecular detection of sexually transmitted infections.

Head of the research group: doc. MVDr. Martin ANGER, CSc.
Phone: +420 533 331 411
E-mail: anger@vri.cz

The activity of the laboratory is focused on the study of chromosome segregation in mammalian meiosis and in early embryonic development, depending on female age. In mammalian oocytes, the incidence of disorders increases with advancing age. The resulting chromosomal aneuploidy is one of the factors responsible for reproductive dysfunctions and has serious consequences giving rise to foetal loss and defects. We use advanced microscopy methods such as live cell imaging to study chromosome division. The research group is involved in the CEITEC project.